MovDisordV3, Main, Exploration, bibRecord, 001C96

Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

Identifieur interne : 001C96 ( Main/Exploration ); précédent : 001C95; suivant : 001C97

Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

Auteurs : Ruksana Azhu Valappil [États-Unis] ; Jed E. Black [États-Unis] ; Meredith J. Broderick [États-Unis] ; Oscar Carrillo [États-Unis] ; Eric Frenette [Canada] ; Shannon S. Sullivan [États-Unis] ; Samuel M. Goldman [États-Unis] ; Caroline M. Tanner [États-Unis] ; James W. Langston [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-10-30.

RBID : ISTEX:8A0C92F63BE7EB6B9C5CA2DA6F74181183A76A9E

English descriptors

KwdEn :
- Aged, Autonomic Nervous System Diseases (etiology), Disease Progression, Electrocardiography, Female, Heart Rate (physiology), Humans, Male, Middle Aged, Nonlinear Dynamics, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson's disease, REM Sleep Behavior Disorder (diagnosis), REM Sleep Behavior Disorder (physiopathology), Retrospective Studies, Statistics, Nonparametric, Time Factors, cardiac autonomic dysfunction, electrocardiogram, heart rate variability, pre‐motor Parkinson's disease..
MESH :
- diagnosis : Parkinson Disease, REM Sleep Behavior Disorder.
- etiology : Autonomic Nervous System Diseases.
- physiology : Heart Rate.
- physiopathology : Parkinson Disease, REM Sleep Behavior Disorder.
- Aged, Disease Progression, Electrocardiography, Female, Humans, Male, Middle Aged, Nonlinear Dynamics, Retrospective Studies, Statistics, Nonparametric, Time Factors.

Abstract

The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age‐matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5‐minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R‐R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R‐R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave‐one‐out cross‐validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD. © 2010 Movement Disorder Society.

Url:

https://api.istex.fr/document/8A0C92F63BE7EB6B9C5CA2DA6F74181183A76A9E/fulltext/pdf

DOI: 10.1002/mds.23348

Affiliations:

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<front><div type="abstract" xml:lang="en">The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age‐matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5‐minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R‐R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R‐R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave‐one‐out cross‐validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD. © 2010 Movement Disorder Society.</div>
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Movement Disorders (revue)

Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
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